NFL Straight Up Picks – NFL Predictions Week 6 (2021)

Best NFL Straight Up Picks Week 6

NFL Schedule Sep 16

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Chiefs vs. Bills
The Chiefs have been showing their Super Bowl potential yet again this season, after already having a huge win against the Baltimore Ravens a few weeks ago. Even though they have sad some slow games, this offense still looks the best in the league by far. Patrick Mahomes and company have been getting it done game after game and hope to do that again this week against a stiff Bills defense. The Bills have been playing exceptional football as well. Some are even calling Josh Allen to be an MVP candidate when this season wraps up. This game has the potential to go back and forth with both of these talented offenses and defenses. However, I think the Bills upset the Chiefs in this game due to their stout defense and big play ability.

Final Pick: Bills


Bengals vs. Colts
Joe Burrow seems to finally be settling himself into the Bengals system as this season goes on. He continues to improve week after week and gives the Bengals a shot to win every game. Although, their defense hasn’t been what it should be so far this season and will need to improve this week if they want to slow down the Colts power rushing attack. The Colts have had a ton of success this season behind Phillip Rivers and Jonathan Taylor, both of whom weren’t on the roster last season. Taylor has proved to be a workhorse for the Colts, which has taken a ton of pressure off of Rivers shoulders and has allowed the Colts to play at their own pace. I would take the Colts here; they are far more experienced than the Bengals and their rushing attack should wear down the Bengals defense.

Final Pick: Patriots

Falcons vs. Vikings
The Falcons still have an incredible offense with a ton of weapons including Julio Jones and Calvin Ridley, but their defense continues to let their offense down. Their defense is just downright terrible in all three stages and doesn’t pose a single threat to opposing offenses, which will get the Falcons in trouble against a Vikings offense that has many talented players. The Vikings will wear down the Falcons defensive line with Dalvin Cook and the second they start to adjust to Cook they will be able to take some shots downfield to Adam Thielen and Justin Jefferson. There are just too many obstacles for the Falcons to overcome in this matchup just to stay in the game. I think the Falcons get off to a hot start but slowly cool down enough for the Vikings to steal this win.

Final Pick: Vikings

Lions vs. Jaguars
The Lions continue to be one of the few teams that are unable to close out a game this season. They have at least three games already in which they were leading by double digits at one point and yet weren’t able to come away with the win in any of them. That cannot happen against Gardner Minshew and the Jacksonville Jaguars. Minshew is always able to bring the most out of his team and should be able to instill enough confidence to keep the Jaguars in the game. The Lions need to put them away when given the chance, they need to continue to dominate ball control and establish their run game in order to take the pressure off of their defense. They should have no problem as the Jaguars defense is among the worst in the league. If they are able to do that then it could be a nice victory for a disappointing Lions team. Take the Lions in this matchup.

Final Pick: Lions

Browns vs. Steelers
The Browns have shown flashes of how dangerous they are able to be, particularly in their Week 4 win against the Dallas Cowboys when they put up 49 points. Their new head coach has been able to put the ball in his playmakers hands and it has been paying dividends for this offense. They should be able to cause problems through the air with Odell Beckham and Jarvis Landry while also pounding the run game with Nick Chubb and Kareem Hunt. Meanwhile, the Steelers have played great football ever since Ben Roethlisberger has come back into the starting lineup and should keep this game very close. This game will come down to which defense can make the most stops and I feel the Steelers defense is a lot more capable of doing so despite having the tougher task. Take the Steelers on this matchup.

Final Pick: Steelers


Jets vs. Chargers
The Jets have been downright terrible in all phases of the game all season long. They have shown very little promise in area with the exception of Sam Darnold and Le’veon Bell. It is yet to be known if Bell is even going to be active for this matchup which makes winning that much more difficult for the porous Jets. The Chargers will most likely be heading into this matchup with rookie quarterback Justin Herbert, who has proved time and time again that he is going to be their franchise quarterback. He should get big numbers through the air against the bad Jets secondary as well as being able to establish a good rushing attack. To make matters even worse for the Jets, they will have tough time protecting Darnold against pass rusher Melvin Ingram and Joey Bosa. I would take the Chargers with confidence in this matchup.

Final Pick: Chargers

Rams vs. 49ers
This is bound to be a very exciting divisional matchup between two great teams. The Rams have continued to prove that they are going back into their Super Bowl form from a few seasons ago but without Todd Gurley this time around. Meanwhile the 49ers have been playing great football despite missing a ton of key starters including starting quarterback Jimmy Garoppolo. The Rams will have a very hard time moving the football due to the 49ers great pass defense and tremendous pass rush which can cause a ton of problems for Jared Goff and the Rams offense. On the other side, the 49ers should have Garoppolo back for this matchup, which is a great sign for their offense, but will need to get the ball into their playmakers hands in order to create big plays. This divisional clash can go either way but take the 49ers in this matchup as their defense should cause far too many issues for the Rams.

Final Pick: 49ers

Texans vs. Titans
The Texans have been very underwhelming since trading away their all pro receiver DeAndre Hopkins. They haven’t had a great rushing attack and their passing attack has struggled without a number one guy. Their defense has also not been helping them, allowing far too many big plays. They match up against the Titans who have dominated ball control behind workhorse Derrick Henry and have had decent performances from their defense so far. The Titans should feed Henry the ball all game, I don’t think the Texans will have an answer for him as he should run all over them. The Titans should win this game.

Final Pick: Titans

Football Team vs. Giants
The Football Team may be switching their quarterback soon if they aren’t able to see enough out of young quarterback Dwayne Haskins despite having a few very talented young players on their offense. Their defense hasn’t been that bad however, but nowhere near enough to make up for their bad offense. Meanwhile, the Giants have been terrible offensively since losing superstar running back Saquon Barkley and it should hurt them yet again this week. They have shown absolutely no promise offensively since losing Barkley and if they aren’t able to score points then they simply wont win this ballgame. Washington should win this game in what should be a low scoring affair.

Final Pick: Football Team

Ravens vs. Eagles
This game shouldn’t be all that close barring serious injuries. The Ravens should be able to do whatever they want against a below average Eagles defense and should score a good amount of points in this matchup. The game goes bad when the Eagles take over on offense. They have not been able to protect Carson Wentz whatsoever so far this season, and it doesn’t help that Wentz is having the worst season of his career so far. They will simply not be able to keep up with the Ravens high flying offense at all in this matchup which should result in an easy win for Baltimore.

Final Pick: Ravens

Bears vs. Panthers
I haven’t been that big of a believer in either of these teams all year so far. The Bears still can’t make up their mind on their starting quarterback which could influence this game heavily. They have overall not been very good on either side of the ball but have the ability to turn it on at any time. The Panthers on the other hand, have consistently proved me wrong week after week, with big wins against the Cardinals and the Chargers without their superstar running back Christian McCaffrey. Their defense also seems to be getting comfortable all across the board. This team is a lot more dangerous than people realize and I think they will be able to take advantage of whichever quarterback is named the starter en route to a victory here.

Final Pick: Panthers

Dolphins vs. Broncos
This will be a battle of two completely unpredictable teams. The Dolphins had a huge game against the Jacksonville Jaguars back in Week 3 but sputtered out in the week following against Seattle. Ryan Fitzpatrick will need to score a good amount of points in a mouth-watering matchup against a banged-up Denver team. The Broncos on the other hand may be getting Drew Lock back for the first time since Week 2, if he isn’t ready to go then Brett Rypien will be the starter for another week. Rypien has played poorly so far in the games that he has started in, throwing too many interceptions. If Lock isn’t able to suit up for this matchup then this game could genuinely go either way. When it comes down to it however, I think the Broncos will be able to get it done in the fourth quarter and pull away with a close victory.
Final Pick: Broncos

Packers vs. Buccaneers
Aaron Rodgers and the Packers continue to make a statement to the rest of the league, showing how potent their offense is with multiple high scoring affairs so far this season. But their matchup this week against the Buccaneers can prove to be a shootout. As Tom Brady is starting to find a great rhythm with his teammates, throwing five touchdowns back in Week 4 against the Los Angeles Chargers. Neither of these defenses are top five units but they both have played incredible football so far this season. This will be a game that is won by the offense and the winner could very well be whoever gets the ball last. As much as Brady and the Buccaneers have improved so far this season, I can’t bet against Rodgers and this explosive offense that should have Davante Adams back.

Final Pick: Packers


Cardinals vs. Cowboys
Both of these teams have been incredibly confusing to pick on through the first five week of the season. The Cardinals showed playoff promise through the first few weeks of the season, but recently lost to the Detroit Lions and the Carolina Panthers without Christian McCaffrey. The Kyler Murray MVP talks have also died down too little to nothing. Their opponent is another team that has been up and down every week. Dallas has so much offensive firepower and Dak Prescott is throwing for 500 yards on a weekly basis at this point. However, their defense has allowed over 120 points in just their first three games of the season and they don’t look to be improving at all so far. These are two of the most unpredictable teams in the league right now, but I think that the Cardinals will be able to come out and make a statement in a bounce back game for them.

Final Pick: Cardinals

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