NFL Straight Up Picks – NFL Predictions Week 4 (2021)

Best NFL Straight Up Picks Week 4

NFL Schedule Sep 16

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Broncos vs. Jets
A few weeks ago, this game would be a Broncos lock but after a slew of injuries to both teams this game may come down to the wire. The Broncos have lost starting quarterback Drew Lock and wide receiver Courtland Sutton but still have one of the better rosters in the league while the Jets lost their star running back Le’veon Bell but also have one of the worst rosters in the league. Even though the tons of injuries will make this game close, the Broncos should be able to handle a weak Jets team that has struggled to find any offensive rhythm.

Final Pick: Broncos


Ravens vs. Football Team
The Ravens are arguably the best team in the NFL right now with reigning MVP Lamar Jackson at the helm. They have an all-around great roster which includes a great offense, defense and even special teams. They are going against a Washington team that is currently 1-1 but lacks talent on both sides of the football. They are a much-improved team compared to last year but are no match for a team that is considered Super Bowl favorites to some.

Final Pick: Ravens

Saints vs. Lions
The Saints will badly need star receiver Michael Thomas back to help stretch out opposing defense even further than they already are. If they are able to confuse this below average Lions defense, then it could be all over for them. The Lions haven’t had a high scoring offense this year so far, they also haven’t been able to close out games. In the games that they have played, they have started out hot on both sides of the football only to have that momentum slip away from them as the game progressed. The Saints should be able to take full advantage of that and win this one handily.

Final Pick: Saints

Colts vs. Bears
The Colts are beginning to become a power running football team. In their Week 2 matchup against the Minnesota Vikings, they handed the ball to rookie running back Jonathan Taylor 26 times. Look for Taylor to remain the workhorse for the Colts offense and to tire out the opposing defense. However, the Bears have one of the best defensive lines in football with Khalil Mack and Akiem Hicks and should be able to slow down their run attack the best they can. This game should come down to the arms of Philip Rivers and Mitchell Trubisky too see which one of these quarterbacks are able to make the least number of mistakes to lead their team to victory. With the improvement of Trubisky so far this season, I expect a big win from the Bears here.

Final Pick: Bears


Chargers vs. Buccaneers
The Chargers looked like a much better football team when rookie quarterback Justin Herbert was the starter. He had spread the ball out well and was able to fit the ball into tight windows frequently. But the downside is that nobody knows who their starting quarterback will be for this matchup as Tyrod Taylors health is a major concern. Meanwhile, the Bucs were finally able to find a groove in their past matchups which include a big bounce back win over the Carolina Panthers in Week 2. They should be even more dangerous with another week of practice to fully get comfortable with the scheme. This will be a very close game, but I am going with the Chargers on this one, only if Herbert is the starter.

Final Pick: Chargers

Cardinals vs. Panthers
The Cardinals have looked great so far in this 2020 season. The addition of DeAndre Hopkins has proved to work wonders so far with young quarterback Kyler Murray, as the two were able to develop incredible chemistry in a very short amount of time. They are going to be matchup up against a very weak Panthers defense that will be without superstar running back Christian McCaffrey. The Cardinals should win this one.

Final Pick: Cardinals

Jaguars vs. Bengals
Minshew Mania is alive and well after last season and it should be a strong factor in this game as well. Jaguars quarterback Gardner Minshew has been able to make each game competitive for them despite having one of the worst rosters in the entire league. They are playing a somewhat equal opponent this week that includes the number one overall pick Joe Burrow. Burrow has proved that he belongs in this league and that he will be a great quarterback someday. But for now, they just don’t have enough help around him in order to win this game. They have to improve that offensive line to give Burrow more time to pass the football. I think the Jaguars take this game.

Final Pick: Jaguars

Seahawks vs. Dolphins
The Seahawks have been letting potential MVP candidate Russell Wilson throw the ball a ton more than in recent years and it is working like a charm. They are scoring at a far increased rate so far and have looked unstoppable at times. They now play a team that has a good amount of talent but has far too many holes to be competitive in this game. The Dolphins also have a number of injuries to key defensive players such as starting cornerback Byron Jones who may miss the game. Which means, in order for the Dolphins to win this game, they will need to keep up with the Seahawks scoring. Ryan Fitzpatrick will need to pull out the heroics in order to do that, I don’t see that happening in this game.

Final Pick: Seahawks

Vikings vs. Texans
The Vikings haven’t looked that great at all on the offensive side of the football so far this season. Kirk Cousins continues to force the ball into Adam Thielen’s hands and is not used to him being double covered consistently after they traded Stefon Diggs. Cousins will need to get back on track in this matchup against a below average Texans secondary. Meanwhile, the Texans will have to put up points more consistently and will need to find an identity for themselves on that side of the ball. They traded their all pro receiver in Hopkins for David Johnson, who hasn’t been used as frequently as he should be. They will need to figure things out and fast, or else the Vikings will take advantage in this matchup. I think the Vikings get a big win here.

Final Pick: Vikings


Steelers vs Titans
The Steelers are looking very good so far this season with Ben Roethlisberger back as the starting quarterback. James Connor has also been able to bounce back from his benching back during the season opener against the Giants. As well as that, their defense has continued to look like a top ten unit in the NFL, which will make things very hard for the Titans in this matchup. The Titans will need to feed Derrick Henry the football quite a bit in order to tire out the Steelers front seven and create more lanes to pass the ball. I think the Steelers have more firepower on both sides of the ball and should be able to beat the Titans in this AFC clash.

Final Pick: Steelers

Browns vs. Cowboys
The Cowboys have looked very sloppy at times in their first few games so far this season. Their fumbling problems back in Week 2 against the Falcons had raised a good amount of concern. However, they are still a very talented team, they just need to improve on the defensive side of the ball and be able to limit their turnovers. They will have the perfect opportunity to do just that against a very talented Browns team that has played pretty well lately. Cleveland will need to get their outstanding running back duo going early against a decent Cowboys defensive line and doing so will be able to create one on one’s with Odell Beckham and Jarvis Landry. The Browns should be able to cause a lot of mismatches on the offensive side of the ball, which is why I am picking them to win this game.

Final Pick: Browns

Bills vs. Raiders
Josh Allen has been able to lead the Bills to a few great wins so far this season and that looks to continue against a poor Raiders defense. The addition of Stefon Diggs has proved to be a great move for the Bills as it has given Allen the best weapon, he has had throughout his young career so far. He is performing at an incredible level and that level of play has transpired over to their defense as well, which remains as one of the best units in the league. Meanwhile, the Raiders have a ton of holes to fill in on both sides of the ball but have shown a ton of promise through the early goings of this season. This will be a very close game but I can’t bet against the Bills in this one.

Final Pick: Bills

Eagles vs. 49ers
The Eagles have looked downright bad throughout the season so far and will need a big game from their offense in order to win this one. Carson Wentz will need to be given time by his offensive line in order for him to make plays downfield so this game lives and dies on the Eagles ability to protect their franchise quarterback. Miles Sanders has been able to give them a great boost to their rushing attack, but they are still far from an elite offense. They are matching up against a 49ers team that has been riddled with injuries so far this year on both sides of the football. This game is the Eagles to lose with all of those injuries. I think the Eagles will be able to finally get it going against this 49ers team that is missing a majority of their starters on both sides of the ball.

Final Pick: Eagles

Giants vs. Rams
The Giants haven’t looked all that great so far this season, but that is too be expected from a team that is severely missing talent. To make matters worse for them they lost superstar running back Saquon Barkley in their Week 2 matchup against the Chicago Bears. Meanwhile, the Rams have been playing at a much-improved level compared to last year and they look to be returning to their Super Bowl form from a few years ago. This game shouldn’t be that close, barring Daniel Jones heroics, and the Rams should be able to dominate in this one.

Final Pick: Rams

Patriots vs. Chiefs
This has the potential to be the game of the year so far if it lives up to the hype. Cam Newton has played incredibly well so far as a member of the Patriots which makes this team very scary to line up against. They are a completely different team since Tom Brady left to go to Tampa. Their defense is also an all-around solid unit that can keep them in ball games. However, they are going up against the reigning Super Bowl champions with Patrick Mahomes and company. This game has the potential to be high scoring, but I can’t bet against Mahomes. Take the Chiefs to win this one.

Final Pick: Chiefs

Falcons vs. Packers
The Falcons have one of the most talented offenses in the league but have one of the worst defenses in the league. They had lost their Week 2 matchup against the Cowboys despite scoring 39 points in the game. Their defense will have to improve a small bit to defeat a talented Packers team that has both a good offense and defense. The Falcons are going to score the ball frequently against this Packers defense, but Aaron Rodgers and company will have a field day marching down the field against the terrible Falcons defense. Take the Packers in this game.

Final Pick: Packers